Physician FAQ / Evidence and method
Every driver traces to a source.
How the evidence behind an AEGIS risk tier is graded, which tiers come from published calculators, and why the same inputs always give the same tier.
Cancer Susceptibility Index (CSI): a per-cancer risk tier derived by a deterministic rules engine from published, peer-reviewed evidence, for review by a licensed healthcare professional. Not a diagnosis, and not a statement that a patient has or will develop cancer.
Every driver traces to published, peer-reviewed evidence, and the reviewing physician can see that evidence in the console. Nothing is hand-tuned or model-generated. The method itself is proprietary and is not described on this site.
IARC, part of the WHO, publishes the Monographs that classify agents by carcinogenicity, for example Group 1 for alcohol, processed meat, and tobacco. WCRF and AICR run the Continuous Update Project, grading diet, body-weight, and activity evidence as convincing, probable, or limited. Both establish whether something causes cancer, which is a hazard judgement. Neither sets the size of the effect.
No, and the console labels which is which. Most tiers come from the deterministic rules engine, which covers 24 cancers. Two use published precision modules instead: female breast risk uses the NCI Gail / BCRAT model, and lung uses PLCOm2012, informational and for ever-smokers only. Both are validated published calculators, and both are named wherever they appear, so a clinician always knows which method produced the number in front of them.
It is deterministic. A rules engine derives each tier from published, peer-reviewed evidence. Ask twice and you get the identical tier, which is what a chart review or a deposition requires. The clinician still makes the decision.
The IARC Monographs and the WCRF Continuous Update Project are living references. The AEGIS evidence matrix is versioned and re-graded as they publish, with each revision dated and auditable.
General information, not advice. This page explains how AEGIS is designed to operate. The interactive console is an illustrative demo, and its values are not engine values.